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艾美捷科技代理Ligatrap品牌全系列产品


LigaTrap Technologies是一家位于北卡罗来纳州的创新型生物技术公司,提供独特的专利技术组合,专注于蛋白质纯化领域。LigaTrap精于抗体与病毒纯化,服务于抗体药物、病毒疫苗及基因治疗产业。


LigaTrap公司产品

● LigaGuard:最新推出的亲和吸附剂,是由多模态配体构成的专利复合体系,可在流穿模式(连续流)下选择性捕获宿主细胞蛋白(HCPs)与DNA。

● AAVidity™:一种新型亲和层析填料,用于血清型普适性纯化 源自 HEK293 和 Sf9 细胞裂解液 的 腺相关病毒(AAV)。

● IgM Resin:专为纯化 IgM 抗体设计的亲和树脂,具有高纯度、高结合能力、温和的洗脱条件(pH 约 4.0),并可重复使用多达 100 次。

● Base Resin:专为从多克隆与单克隆来源中纯化高质量抗体而设计,该树脂推荐用于纯化:多种物种的 IgG(包括人、小鼠、兔等);人源 IgA;鸡源 IgY。

● LigaTrap Buffers:包含Regeneration Buffer,Neutralization Buffer,Elution Buffer,Regeneration Buffer,Equilibration/Wash Buffer 2.0等。


Ligatrap.png


LigaGuard

LigaGuard™树脂适用于两类核心产品的纯化:蛋白制品:单克隆抗体、生长因子;病毒制品:慢病毒、腺相关病毒(AAV)、病毒疫苗。该树脂的设计使目标生物产物无结合通过,实现高纯度与高回收率。其能清除传统纯化工艺难以去除的高残留性HCPs(HR-HCPs),显著提升终产物的纯度、稳定性、疗效与安全性。

品名货号规格
LigaTrap LigaGuard 1 ml Packed ColumnLT-LG1-1x1mL1mL
LigaTrap LigaGuard 5ml Packed ColumnLT-LG1-1x5mL5mL
LigaTrap LigaGuard Loose Resin - 5mLLT-LG15 mL
LigaTrap LigaGuard Loose Resin - 10mLLT-LG1-10mL10 mL
LigaTrap LigaGuard Loose Resin - 25mLLT-LG1-25mL25 mL
LigaTrap LigaGuard Loose Resin - 50mLLT-LG1-50mL50 mL
LigaTrap LigaGuard Loose Resin - 100mLLT-LG1-100mL100 mL


AAVidity

AAVidity填料通过合成亲和配体功能化修饰,可捕获所有血清型的 AAV,提供卓越的结合载量与污染物(宿主细胞蛋白 HCPs 及宿主细胞DNA hcDNA清除能力。其温和洗脱条件在保障 AAV 转导活性的同时,实现高产物回收率。

品名货号规格
LigaTrap AAVidity Loose Resin – 1mLLT-AAV-1mL1mL
LigaTrap AAVidity Loose Resin – 5mLLT-AAV-5mL5mL
LigaTrap AAVidity Prepacked Column – 1mLLT-AAV-1x1mL1x1mL
LigaTrap AAVidity Prepacked Column – 5mLLT-AAV-1x5mL1x5mL


▍IgM Resin

 IgM纯化树脂的核心优势包括:

● 全面捕获:同时结合IgM的重链与轻链亚型;

● 零风险:无免疫原性及配体脱落;

● 活性保全:温和洗脱条件保障抗体完整性;

● 经济耐用:消毒再生后可重复使用 ≥100 次;

● 该树脂能高效处理并纯化来自以下样本的单克隆 IgM:细胞培养上清,腹水,杂交瘤,其他重组 IgM 来源。

品名货号规格
IgM Microspin Column Kit w/ BuffersLT-155KITKIT-10x0.1mL
IgM 1mL Prepacked Column Kit w/ BuffersLT-155-1mL KITKIT-1x1mL
IgM 5mL Prepacked Column Kit w/ BuffersLT-155-5mL KITKIT-1x5mL
IgM Loose Resin – 5mLLT-1555mL
IgM Loose Resin – 10mLLT-155-10mL10mL
IgM Loose Resin – 25mLLT-155-25mL25mL
IgM Loose Resin – 50mLLT-155-50mL50mL
IgM Loose Resin – 100mLLT-155-100mL100mL
IgM Microspin Columns without BuffersLT-155-MSC10x0.1mL
IgM Prepacked Column – 1mLLT-155-1x1mL1x1mL
IgM Prepacked Column – 5mLLT-155-1x5mL1x5mL
IgM Prepacked Columns – 3x1mLLT-155-3x1mL3x1mL

▍Base Resin

LigaTrap基础纯化树脂可实现高回收率与>95%的纯度,而传统Protein A和Protein G填料的回收率甚至低于检测限。通过优化工艺,该树脂的纯度可进一步提升至99%。

品名货号规格
Base Resin Microspin Column Kit w/ BuffersLT-150KITKIT-10x0.1mL
Base Resin 1mL Prepacked Column Kit w/ BuffersLT-150-1mL KITKIT-1x1mL
Base Resin 5mL Prepacked Column Kit w/ BuffersLT-150-5mL KITKIT-1x5mL
Loose Base Resin – 5mLLT-1505mL
Loose Base Resin – 10mLLT-150-10mL10mL
Loose Base Resin – 25mLLT-150-25mL25mL
Loose Base Resin – 50mLLT-150-50mL50mL
Loose Base Resin – 100mLLT-150-100mL100mL
Base Resin Microspin Columns without BuffersLT-150-MSC10x0.1mL
Base Resin Prepacked Column – 1mLLT-150-1x1mL1x1mL
Base Resin Prepacked Column – 5mLLT-150-1x5mL1x5mL
Base Resin Prepacked Columns – 3x1mLLT-150-3x1mL3x1mL


▍Buffers

品名货号规格
LigaTrap Elution BufferBU-123-FP125ml
LigaTrap Regeneration BufferBU-124-FP50ml
LigaTrap Neutralization BufferBU-125-FP15ml
LigaTrap Storage BufferBU-126-FP50 ml
LigaTrap Sample Diluent 2.0BU-131-FP15 ml
LigaTrap Equilibration/Wash Buffer 2.0BU-132-FP250ml
LigaTrap IgM Elution Buffer pH 3.8BU-133-FP125 ml
LigaTrap Elution BufferBU-123-500-FP500ml
LigaTrap Regeneration BufferBU-124-500-FP500 ml
LigaTrap Neutralization BufferBU-125-250-FP250 ml
LigaTrap Storage BufferBU-126-500-FP500 ml
LigaTrap Sample Diluent 2.0BU-131-250-FP250 ml
LigaTrap Equilibration/Wash Buffer 2.0BU-132-1-FP1L
LigaTrap IgM Elution Buffer pH 3.8BU-133-500-FP500ml


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ViroStat.jpg

ViroStat于1985年,由Douglas McAllister博士创立,致力于为研究者和工业界提供传染性疾病的抗体产品。产品线涵盖病毒学、细菌学和寄生虫学,应用于呼吸道药、性病药、胃肠药/毒素和食源性致病菌的检测。ViroStat拥有超过500种传染性疾病相关的试剂,其中包括MONOTOPE系列单克隆抗体、PMNITOPE多克隆抗体和数量众多的重组蛋白抗原。基于长期的经验积累,ViroStat能够提供从100ug到10g级别的产品。

 

ViroStat was founded in 1985 by Dr. Douglas McAllister to provide infectious disease antibody tools to researchers and manufacturers. These include the areas of virology, bacteriology and parasitology. Applications for these include detection of respiratory agents, STD agents, gastrointestinal agents/toxins and food borne pathogens.

 

The company offers more than 500 infectious disease reagents including their MONOTOPE™ monoclonal antibodies, OMNITOPE™ polyclonal antibodies and numerous recombinant antigens. Many of these antibodies are used by manufacturers of rapid, point of care tests currently made and sold in the US.

 

ViroStat公司产品包括:

MONOTOPE™ - Monoclonal Antibodies (Mouse) 小鼠单克隆抗体

RABMAB® - Monoclonal Antibodies (Rabbit) 兔单克隆抗体

OMNITOPE™ - Polyclonal Antibodies多克隆抗体

RECOMBINANT ANTIGENS 重组抗原

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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Epitope Diagnostics.jpg

艾美捷科技代理Epitope Diagnostics全系列抗体及试剂盒产品。

Epitope Diagnostics是一家经过ISO 13845认证的医疗器械制造公司,位于圣地亚哥的索伦托谷生物技术中心。Epitope专门从事全球医疗设备和诊断行业的分析开发和制造。公司涉足领域包括胃肠道,心血管,感染和自身免疫性疾病,以及肿瘤/癌症和钙/骨代谢。Epitope Diagnostics Inc. (EDI) strives to develop, manufacture, and market the highest quality and most innovated in-vitro diagnostics (IVD) products to the global research, pharmaceutical, and healthcare community. We seek to become a major contributor in resolving the unmet medical needs of the world.


Epitope Diagnostics公司的主要产品包括:

ANTIBODIES
MAB30699Anti-MMAE Monoclonal Antibody
MAB30699bBiotinylated Anti-MMAE Monoclonal Antibody
MAB30700Anti-MMAF Monoclonal Antibody
MAB30700bBiotinylated Anti-MMAF Monoclonal Antibody
30698Anti-DM1 Polyclonal Antibody
30699Anti-MMAE Polyclonal Antibody
30700Anti-MMAE Polyclonal Antibody
30618Anti-Human FGF-21 N-terminal Specific Antibody, Affinity Purified
30661Anti-Human FGF-21 C-terminal Specific Antibody, Affinitiy Purified
30704Anti-Human Chromogranin A Monoclonal Antibody, Murine
30705Anti-Human Chromogranin A Polyclonal Antibody, Sheep
30706Anti-Human Chromogranin A N-terminal Polyclonal Antibody, Rabbit
30713Anti-Human Chromogranin A N/mid-regional Polyclonal Antibody, Rabbit
30714Anti-Human Chromogranin A C/mid-regional Polyclonal Antibody, Rabbit
30715Anti-Human Chromogranin A C-terminal Polyclonal Antibody, Rabbit
30657Anti-Human NGAL Polyclonal Antibody (IgG), Sheep
30658Anti-Human NGAL Polyclonal Antibody, Sheep, Affinity Purified



TUMOR MARKERS & CANCER RESEARCH
KT-810Human Pepsinogen I ELISA Kit96 tests/kit
KT-811Human Pepsinogen II ELISA Kit96 tests/kit
KT-812Human Chromogranin A ELISA Kit (1st generation)96 tests/kit
KT-820Human Chromogranin A ELISA Kit (2nd generation)96 tests/kit
KT-855Human Chromogranin A ELISA Kit (2nd generation, wide range)96 tests/kit
KT-817Human Neuron Specific Enolase ELISA Kit96 tests/kit
KT-850q-FOB™ Quantitative Fecal Occult Blood Test ELISA Kit96 tests/kit
30210Fecal Sample Collection Device for q-FOB™50 tubes/kit
KT-111FOB Cassette Test Kit20 tests/kit
KT-705Intact Brentuximab Vedotin ELISA KIt96 tests/kit
KT-706Trastuzumab Emtansine EIA Kit96 tests/kit
KTR-755Humanized Anti-Her2/neu (Herceptin/trastuzumab) ELISA Kit96 tests/kit
KTR-756DM1 ADC EIA Kit96 tests/kit
KTR-757MMAE ADC EIA Kit96 tests/kit
KTR-758MMAF ADC EIA Kit96 tests/kit
KTR-782Intact MMAE ADC ELISA Kit96 tests/kit
KTR-783Intact MMAF ADC ELISA Kit96 tests/kit



GASTROINTESTINAL DISEASE-Serum ELISA Kits
KT-810Human Pepsinogen I ELISA Kit96 tests/kit
KT-811Human Pepsinogen II ELISA Kit96 tests/kit
KT-830Human Anti-Gliadin IgA EIA Kit96 tests/kit
KT-831Human Anti-Gliadin IgG EIA Kit96 tests/kit
KT-845Human Anti-Giardia lamblia IgA ELISA Kit96 tests/kit
KT-846Human Anti-Giardia lamblia IgG ELISA Kit96 tests/kit
KT-847Human Anti-Giardia lamblia IgM ELISA Kit96 tests/kit



GASTROINTESTINAL DISEASE-Fecal ELISA Kits
KT-824Qualitative Fecal H. pylori Antigen ELISA Kit96 tests/kit
KT-826Quantitative Fecal H. pylori Antigen ELISA Kit96 tests/kit
KT-828Fecal C. difficile GDH ELISA Kit96 tests/kit
KT-834Fecal C. difficile Toxin A ELISA Kit96 tests/kit
KT-835Fecal C. difficile Toxin B ELISA Kit96 tests/kit
KT-836Fecal C. difficile Toxin A & B ELISA Kit96 tests/kit
KT-837Fecal E. coli 0157 ELISA Kit96 tests/kit
KT-838Fecal Giardia lamblia Antigen ELISA Kit96 tests/kit
KT-839Fecal Cryptosporidium parvum Antigen ELISA Kit96 tests/kit
KT-841Fecal Rotavirus Antigen ELISA Kit96 tests/kit
KT-842Fecal Adenovirus Antigen ELISA Kit96 tests/kit
KT-849Quantitative Fecal Calprotectin ELISA Kit96 tests/kit
KT-850q-FOB™ Quantitative Fecal Occult Blood Test ELISA Kit96 tests/kit
KT-853Quantitative Fecal NGAL ELISA Kit96 tests/kit
KT-880Quantitative Fecal/Urine Myeloperoxidase ELISA Kit96 tests/kit



GASTROINTESTINAL DISEASE-Fecal Sample Collection Kits
KT-854Fecal H. pylori Sample Collection Kit50 tubes/kit
KT-864Fecal H. pylori/GDH/Toxin A&B Sample Collection Kit48 tubes/kit
KT-843Fecal Calprotectin Sample Collection Kit50 tubes/kit
30210q-FOB™ Fecal Sample Collection Device 50 tubes/kit
KT-844Fecal MPO Sample Collection Kit48 tubes/kit
KT-884Fecal NGAL Sample Collection Kit48 tubes/kit
FPC200Fecal Ova/Parasite Concentration Kit50 tubes/kit



GASTROINTESTINAL DISEASE-Rapid Tests
KT-313EpiTuub® Immunochemical Fecal Occult Blood Rapid Test Kit30 tests/kit
KT-917EpiTuub® Fecal Rotavirus Antigen Rapid Test Kit30 tests/kit
KT-918EpiTuub® Fecal Adenovirus Antigen Rapid Test Kit30 tests/kit
KT-920EpiTuub® Fecal Calprotectin Rapid Test Kit30 tests/kit
KT-921EpiTuub® Fecal Calprotectin Rapid Test Kit10 tests/kit
KT-922EpiTuub® Calprotectin/i-FOB DUO Test30 tests/kit
KT-926EpiTuub® Fecal Rota-Adeno Duo Antigen Rapid Test Kit30 tests/kit
KT-927EpiTuub® Fecal Giardia lamblia Antigen Rapid Test Kit30 tests/kit
KT-928EpiTuub® Fecal Cryptosporidiun parvum Antigen Rapid Test Kit30 tests/kit
KT-929EpiTuub® Fecal H. pylori Antigen Rapid Test Kit30 tests/kit
KT-935EpiTuub® Fecal C. difficile Antigen Rapid Test Kit30 tests/kit



GASTROINTESTINAL DISEASE-Strip Test Kit
KT-313sImmunochemical Fecal Occult Blood Strip Test Kit50 strips/kit
KT-917sFecal Rotavirus Antigen Strip Test Kit50 strips/kit
KT-918sFecal Adenovirus Antigen Strip Test Kit50 strips/kit
KT-920sFecal Calprotectin Strip Test Kit50 strips/kit
KT-927sFecal Giardia lamblia Antigen Strip Test Kit50 strips/kit
KT-928sFecal Cryptosporidium parvum Antigen Strip Test Kit50 strips/kit
KT-929sFecal H. pylori Antigen Strip Test Kit50 strips/kit
KT-935sFecal C. difficile Antigen Strip Test Kit50 strips/kit



GASTROINTESTINAL DISEASE-Cassette Test Kits
KT-111FOB Cassette Test Kit20 tests/kit
KT-112Calprotectin Cassette Test Kit20 tests/kit
KT-113H. pylori Cassette Test Kit20 tests/kit



INFECTIOUS DISEASE
KT-851Varicella Zoster Virus (VZV) IgG ELISA Kit96 tests/kit
KT-867HAV IgG ELISA Kit96 tests/kit
KT-868HAV IgM ELISA Kit,μ-Capture Method96 tests/kit
KT-869Total HAV Antibody ELISA Kit96 tests/kit
KT-897Zika Virus IgG ELISA Kit96 tests/kit
KT-898Zika Virus IgM ELISA Kit,μ-Capture Method96 tests/kit
KT-1011HBeAg ELISA Kit96 tests/kit
KT-1015H. pylori IgG ELISA Kit96 tests/kit
KT-1018HEV IgG ELISA Kit96 tests/kit
KT-1019HEV IgM ELISA Kit,μ-Capture Method96 tests/kit
KTR-1020Toxoplasma gondii IgG ELISA Kit96 tests/kit
KTR-1021Toxoplasma gondii IgM ELISA Kit,μ-Capture Method96 tests/kit
KTR-1022Rubella IgG ELISA Kit96 tests/kit
KTR-1023Rubella IgM ELISA Kit,μ-Capture Method96 tests/kit
KTR-1024Cytomegalovirus (CMV) IgG ELISA Kit96 tests/kit
KTR-1025Cytomegalovirus (CMV) IgM ELISA Kit,μ-Capture Method96 tests/kit
KT-1026HSV 1+2 IgG ELISA Kit,μ-Capture Method96 tests/kit
KT-1027HSV 1+2 IgM ELISA Kit,μ-Capture Method96 tests/kit
KT-1028HSV-1 IgG ELISA Kit96 tests/kit
KT-1029HSV-1 IgM ELISA Kit,μ-Capture Method96 tests/kit
KT-1030HSV-2-IgG ELISA Kit96 tests/kit
KT-1031HSV-2 IgM ELISA Kit,μ-Capture Method96 tests/kit
KT-1032Coronavirus COVID-19 IgG ELISA Kit - qualitative, N protein target, CE marked96 tests/kit
KT-1033Coronavirus COVID-19 IgM ELISA Kit - qualitative, N protein target, CE marked96 tests/kit
KT-1034COVID-19 Nucleocapsid IgG Quantitative ELISA Kit - CE marked96 tests/kit
KTR-1035Quantitative SARS-CoV-2 Spike Protein IgG ELISA - CE marked96 tests/kit
KTR-1036Quantitative SARS-CoV-2 Neutralizing Antibody ELISA - CE marked96 tests/kit



CARDIOVASCULAR DISEASE
KT-800Human Fetuin-A ELISA Kit96 tests/kit
KT-900High Sensitive Human Fetuin-A ELISA Kit96 tests/kit
KT-883Human Plasma NGAL ELISA Kit96 tests/kit
KT-885Plasma Calprotectin ELISA Kit96 tests/kit
KT-890Quantitative Serum/Plasma Myeloperoxidase ELISA Kit96 tests/kit



CALCIUM/BONE METABOLISM
KT-809Human Osteocalcin (1-43/49) ELISA Kit96 tests/kit
KT-715Total 25-OH Vitamin D EIA Kit (Two wash steps)96 tests/kit
KT-815Total 25-OH Vitamin D EIA Kit (Three wash steps)96 tests/kit
KT-888Human Intact PTH ELISA Kit96 tests/kit
KT-896Human VDBP ELISA Kit96 tests/kit
KT-819Human Growth Hormone ELISA Kit96 tests/kit
KT-840Human Anti-CaSR IgG ELISA Kit96 tests/kit



ENDOCRINOLOGY/DIABETES
KT-804Human Anti-Müllerian Hormone ELISA Kit96 tests/kit
KT-809Human Osteocalcin (1-43/49) ELISA Kit96 tests/kit
KT-819Human Growth Hormone ELISA Kit96 tests/kit
KT-871Active GLP-1 (7-36) ELISA Kit96 tests/kit
KT-876Total GLP-1 ELISA Kit96 tests/kit
KT-602Total GLP-1 ELISA Kit96 tests/kit
KT-910GLP-1 Sample Solid Phase Extraction Kit50 columns/kit
KTR-873Human FGF-21 N-terminal specific ELISA Kit96 tests/kit
KTR-874Human FGF-21 C-terminal specific ELISA Kit96 tests/kit
KT-879Human Intact FGF-21 ELISA Kit96 tests/kit
KT-886Human Insulin ELISA Kit96 tests/kit
KT-887Human High Sensitive Insulin ELISA Kit96 tests/kit
KTR-888Human Intact PTH ELISA Kit96 tests/kit
KT-881Human C-peptide ELISA Kit96 tests/kit
KT-882Human ACTH ELISA Kit96 tests/kit
KT-891Human High Sensitive C-peptide ELISA Kit96 tests/kit



AUTOIMMUNE DISEASE
KT-802Human Anti-FcεRIα Autoantibody ELISA Kit96 tests/kit
KT-803Human Anti-IgE Autoantibody ELISA Kit96 tests/kit
KT-830Human Anti-Gliadin IgA EIA Kit96 tests/kit
KT-831Human Anti-Gliadin IgG EIA Kit96 tests/kit
KT-832Human Anti-Tg IgG ELISA Kit96 tests/kit
KT-833Human Anti-TPO IgG ELISA Kit96 tests/kit
KT-840Human Anti-CaSR IgG ELISA Kit96 tests/kit



MISCELLANEOUS KITS
KT-805HAMA (Human Anti-Mouse Antibody) ELISA Kit96 tests/kit
KT-806HAHA (Human Anti-Human Antibody) ELISA Kit96 tests/kit
KT-807MAHA (Mouse Anti-Human Antibody) ELISA Kit96 tests/kit
KT-751Haptoglobin Immunoturbidimetric AssayInquire


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全国服务热线:400-6800-868

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网站:www.amyjet.com

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Alfa Aesar.png

Alfa Aesar(阿法埃莎)是一家科研化学品、金属和材料的生产商及供应商,公司产品在各种应用领域的研究和开发中发挥着重要的作用,凭借多年的生产经验,该公司的化学师们掌握了大量的技能和经验,利用从实验室规模到中试工厂再到商业化批量生产的工艺路线,向客户交付出优质的化学产品。Alfa Aesar在全球各地的许多工厂从事化学合成生产。在英国西北部的Heysham工厂是该公司的主要实验室之一,经验丰富的开发和生产团队可交付各种产品,以满足制药到半导体、结构材料和成像的各行业客户的需要。

 

Alfa Aesar的主要产品包括:

Chemicals (32249)

Education (2205)

Life Sciences (1463)

Diagnostic Tests and Clinical Products (1213)

Cell Culture (255)

Electrophoresis, Western Blotting and ELISA (113)

Testing and Filtration (88)

Healthcare (80)

Thermometers, pH Meters, Timers and Clocks (70)

Beakers, Bottles, Cylinders and Glassware (63)

Spatulas, Forceps and Utensils (33)

Wipes, Towels and Cleaning (31)

Histology and Cytology (26)

Dishes, Plates and Flasks (18)

Production (15)

Balances, Scales and Weighing (14)

Desiccation and Evaporation (14)

Spectrophotometers, Refractometers and Benchtop Instruments (13)

Chromatography (11)

Gloves, Glasses and Safety (9)

Sonicators, Homogenizers and Blenders (8)

Pumps and Tubing (5)

Instrument Lamps, Lighting and Electrical (4)

Microscopes, Slides and Coverslips (4)

Clamps, Stands and Supports (2)

Test Tubes, Vials, Caps and Closures (2)

Animal Research (1)

Filtration (1)

Incubators, Hot Plates, Baths and Heating (1)

Mixers, Shakers and Stirrers (1)

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Dendritics.jpg

Dendritics公司主要关注人类树突状细胞,希望找到能够促使CD34+造血前体细胞转化为树突状细胞(在GM-CSF和TNF-alpha存在的情况下)的细胞因子。在1992-2005年间,大量的研究使得研究者对人类树突状细胞的产生、细胞通路、C-type凝集素受体的功能及Toll-like受体的活性有了更深的理解。

 

DENDRITICS was started in 2005 by former members of SCHERING PLOUGH Laboratory for Immunological Research (LIR) in Dardilly, France. From their long experience at LIR, the team members of DENDRITICS have gathered complementary scientific and technological knowledge in different areas of immunology. The initial focus of LIR was in the biology of B lymphocytes, elaboration of human monoclonal antibodies, and in cytokine discovery (IL-3, IL-4, IL-7, IL-10, IL-17, GM-CSF) together with our colleagues of DNAX Research Institute in Palo Alto, California.

 

Our interest in cytokines led to the finding that human dendritic cells (DCs) could be generated in vitro from CD34+ hematopoietic progenitors cultured in the presence of GM-CSF and TNF-alpha.

 

The period from 1992 to 2005 saw the specialization of LIR in DC biology and was fuelled by a large-scale effort to discover and study the function of genes specifically expressed by these cells. This program led to a number of findings that contributed in particular to understanding the heterogeneity of DCs, the pathways regulating DC migration, the function of C-type lectin receptors in DCs and the activity of Toll-like receptors in DCs. Many novel genes were discovered through screening of cDNA libraries or through monoclonal antibodies raised against DCs.

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